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[14C]狄氏剂在沙漠蝗中的代谢归宿,特别涉及神经系统。

Metabolic fate of [14C]dieldrin in Schistocerca gregaria with particular reference to the nervous system.

作者信息

Singh G J, Thornhill R A

出版信息

Xenobiotica. 1980 Jan;10(1):57-63. doi: 10.3109/00498258009033731.

Abstract
  1. In the metabolism of [14C]dieldrin in Schistocerca gregaria, four metabolites of dieldrin were detected. Three of these have been identified as cis-aldrindiol, trans-aldrindiol and seco-aldrin dicarboxylic acid. 2. Apart from the formation of cis and trans-aldrindiol, another metabolite, M1, was detected in the nervous system. 3. The uptake of the dose of dieldrin was maximal in nerve cords followed by thoracic muscles and gut. Degradation of dieldrin was, however, not detected in thoracic muscles.
摘要
  1. 在沙漠蝗中[14C]狄氏剂的代谢过程中,检测到了狄氏剂的四种代谢产物。其中三种已被鉴定为顺式狄氏醇、反式狄氏醇和开环狄氏二羧酸。2. 除了顺式和反式狄氏醇的形成外,在神经系统中还检测到另一种代谢产物M1。3. 狄氏剂剂量的摄取在神经索中最高,其次是胸肌和肠道。然而,在胸肌中未检测到狄氏剂的降解。

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