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Stereocontrolled synthesis of 7-oxabicyclo (2.2.1) heptane prostaglandin analogs as thromboxane A2 antagonists.

作者信息

Sprague P W, Heikes J E, Harris D N, Greenberg R

出版信息

Adv Prostaglandin Thromboxane Res. 1980;6:493-6.

PMID:7189952
Abstract
摘要

相似文献

1
Stereocontrolled synthesis of 7-oxabicyclo (2.2.1) heptane prostaglandin analogs as thromboxane A2 antagonists.
Adv Prostaglandin Thromboxane Res. 1980;6:493-6.
2
7-Oxabicyclo[2.2.1]heptane analogs as modulators of the thromboxane A2 and prostacyclin receptors.7-氧杂双环[2.2.1]庚烷类似物作为血栓素A2和前列环素受体的调节剂。
Adv Prostaglandin Thromboxane Leukot Res. 1983;11:337-43.
3
Novel 7-oxabicyclo[2.2.1]heptane prostacyclin agonists.新型7-氧杂双环[2.2.1]庚烷前列环素激动剂。
Adv Prostaglandin Thromboxane Leukot Res. 1983;11:293-7.
4
Aza-substituted omega-side-chain modifications of 7-oxabicyclo[2.2.1]heptane thromboxane A2 receptor antagonists: structure-activity relationships.
Adv Prostaglandin Thromboxane Leukot Res. 1985;15:291-3.
5
Synthesis and in vitro pharmacology of 7-oxabicyclo[2.2.1]heptane analogues of thromboxane A2/PGH2.
J Med Chem. 1985 Nov;28(11):1580-90. doi: 10.1021/jm00149a007.
6
Synthesis and pharmacological evaluation of 5,6-exo-epoxy-7-oxabicyclo[2.2.1]heptane derivatives.5,6-外向-环氧-7-氧杂双环[2.2.1]庚烷衍生物的合成与药理评价
J Med Chem. 1988 May;31(5):930-5. doi: 10.1021/jm00400a007.
7
Synthesis of thromboxane receptor antagonists with bicyclo[3.1.0]hexane ring systems.
J Med Chem. 1990 Jan;33(1):229-39. doi: 10.1021/jm00163a038.
8
Prostaglandin endoperoxides and thromboxanes: role in platelets and in vascular and respiratory smooth muscle.前列腺素内过氧化物和血栓烷:在血小板以及血管和呼吸道平滑肌中的作用。
Acta Biol Med Ger. 1976;35(8-9):1055-63.
9
Synthesis of prostanoids with bicyclo[2.2.1]heptane, bicyclo[3.1.1]heptane, and bicyclo[2.2.2]octane ring systems. Activities of 15-hydroxy epimers on human platelets.具有双环[2.2.1]庚烷、双环[3.1.1]庚烷和双环[2.2.2]辛烷环系的前列腺素的合成。15-羟基差向异构体对人血小板的活性。
J Med Chem. 1982 May;25(5):495-500. doi: 10.1021/jm00347a004.
10
Modulation of human platelet function by prostacyclin and thromboxane A2.前列环素和血栓素A2对人血小板功能的调节
Fed Proc. 1979 Jan;38(1):83-8.

引用本文的文献

1
Endothelium modulates vasoconstrictor response to prostaglandin I2 in rat mesenteric resistance arteries: interaction between EP1 and TP receptors.内皮细胞调节大鼠肠系膜阻力动脉对前列环素 I2 的血管收缩反应:EP1 和 TP 受体的相互作用。
Br J Pharmacol. 2009 Dec;158(7):1787-95. doi: 10.1111/j.1476-5381.2009.00459.x.
2
Pinane thromboxane A2 analogues are non-selective prostanoid antagonists in rat and human stomach muscle.蒎烷血栓素A2类似物在大鼠和人胃肌中是非选择性类前列腺素拮抗剂。
Br J Pharmacol. 1982 Dec;77(4):591-6. doi: 10.1111/j.1476-5381.1982.tb09336.x.