一类新型高活性孕激素：17α-CH2X取代的孕-4,9(10)-二烯。58. 甾体类化合物
[A new class of highly active progestagens: 17 alpha-CH2X-substituted gona-4,9(10)-dienes. 58. Steroids].
作者信息
Hübner M, Ponsold K, Oettel M, Freund R
出版信息
Arzneimittelforschung. 1980;30(3):401-6.
PMID:7190016
Abstract
The synthesis of new gona-4,9(10)-dienes with a 17 alpha-CH2X-substituent (X = CN, N3, Cl or Br) is described. The progestagenic activity of these substances was studied in the McPhail assay using immature rabbits. The compound XVI (X = CN, STS 557) is the most potent one, showing an activity about ten times higher than D-norgestrel. Differences in the activity caused by different routes of application are discussed.
摘要
描述了具有17α-CH2X取代基（X = CN、N3、Cl或Br）的新型孕甾-4,9(10)-二烯的合成。使用未成熟兔，通过麦克菲尔试验研究了这些物质的孕激素活性。化合物XVI（X = CN，STS 557）是活性最强的一种，其活性比D-炔诺孕酮高约十倍。讨论了不同给药途径导致的活性差异。
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