STS 557，一种新型口服活性孕激素，在兔子身上具有抗孕激素和抗孕作用。

STS 557, a new orally active progestin with antiprogestational and contragestational properties in rabbits.

作者信息

Oettel M, Kurischko A

出版信息

Contraception. 1980 Jan;21(1):61-9. doi: 10.1016/0010-7824(80)90140-7.

Abstract

STS 557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4.9(10)-diene-3-one) is a potent progestin. This compound was 10 times as potent as the standard levonorgestrel as judged by the classic Clauberg-McPhail Assay. The antiprogestational response is significant when STS 557 treatment starts 2 days before progesterone administration. It does not disturb the priming activity of estradiol. This compound alone is adequate for endometrial priming. Early pregnancy is maintained in ovariectomized does. Administration on day 1 of pregnancy reduces the number of implantations. In comparison with chlormadinone acetate and d-norgestrel, only STS 557 treatment causes complete inhibition of egg fertilization.

摘要

STS 557（17α-氰甲基-17β-羟基-雌甾-4,9(10)-二烯-3-酮）是一种强效孕激素。根据经典的克劳伯格-麦克费尔试验判断，该化合物的效力是标准左炔诺孕酮的10倍。当在给予孕酮前两天开始用STS 557治疗时，抗孕激素反应显著。它不会干扰雌二醇的启动活性。仅这种化合物就足以使子宫内膜启动。在切除卵巢的母兔中可维持早期妊娠。在妊娠第1天给药会减少着床数量。与醋酸氯地孕酮和d-炔诺孕酮相比，只有STS 557治疗会导致完全抑制卵子受精。