人体红细胞儿茶酚-O-甲基转移酶活性与交感神经活动指标

Erythrocytes catechol-O-methyltransferase activity and indices of sympathetic activity in man.

Fitzgerald G A, Hamilton C A, Jones D H, Reid J L

Clin Sci (Lond). 1980 May;58(5):423-5. doi: 10.1042/cs0580423.

Abstract

Erythrocyte catechol-O-methyltransferase was studied in a population sample of 147 subjects. 2. There was a wide interindividual variability of catechol-O-methyltransferase activity, which was not unimodally distributed. Catechol-O-methyltransferase activity was not influenced by blood pressure, age or sex, nor was it related to plasma noradrenaline or urinary catecholamines or metanephrines. 3. It is not likely that inactivation of noradrenaline by O-methylation at least by erythrocytes is an important mechanism determining plasma noradrenaline, let alone arterial pressure.

摘要

对147名受试者的群体样本进行了红细胞儿茶酚-O-甲基转移酶研究。2. 儿茶酚-O-甲基转移酶活性存在广泛的个体间差异，并非呈单峰分布。儿茶酚-O-甲基转移酶活性不受血压、年龄或性别的影响，也与血浆去甲肾上腺素、尿儿茶酚胺或甲氧基肾上腺素无关。3. 至少由红细胞通过O-甲基化使去甲肾上腺素失活不太可能是决定血浆去甲肾上腺素的重要机制，更不用说动脉血压了。