Srichaijul T, Boonpucknavig S, Archararit N, Chaisiri-pumkeeree W
Arch Intern Med. 1980 May;140(5):636-8. doi: 10.1001/archinte.140.5.636.
Corticosteroids, cyclophosphamide, and splenectomy were employed in the treatment of 43 patients with immunologic thrombocytopenic purpura. All received corticosteroids initially; 22 patients received corticosteroids and cyclophosphamide, and six received drug treatment and underwent splenectomy. Of those receiving corticosteroids alone, 11 had excellent responses and ten had good responses. Of those receiving corticosteroids and cyclophosphamide, responses to treatment were excellent in six, good in eight, and fair in two. Of those receiving drug treatment and undergoing splenectomy, the responses to treatment were excellent in four, good in one, and fair in one. The duration required for induction of remission indicated the prognosis for patients; excellent responses were observed at 1, 2.4, and 4 months in groups treated, respectively, with corticosteroids, corticosteroids and cyclophosphamide, and drugs plus splenectomy.
采用皮质类固醇、环磷酰胺和脾切除术治疗43例免疫性血小板减少性紫癜患者。所有患者最初均接受皮质类固醇治疗；22例患者接受皮质类固醇和环磷酰胺治疗，6例接受药物治疗并接受了脾切除术。在仅接受皮质类固醇治疗的患者中，11例反应极佳，10例反应良好。在接受皮质类固醇和环磷酰胺治疗的患者中，6例治疗反应极佳，8例良好，2例一般。在接受药物治疗并接受脾切除术的患者中，4例治疗反应极佳，1例良好，1例一般。诱导缓解所需的时间表明了患者的预后；分别接受皮质类固醇、皮质类固醇和环磷酰胺以及药物加脾切除术治疗的组中，在1个月、2.4个月和4个月时观察到了极佳的反应。
