Held H
Arzneimittelforschung. 1980;30(5):843-6.
Serum protein binding of (+)-6-methoxy-alpha-methyl-2-naphthaline acetic acid (naproxen) is considerably reduced in patients with hepatocellular or obstructive icterus, respectively. There is a significant negative correlation between serum bilirubin concentration and serum protein binding of naproxen. However, bilirubin cannot be responsible exclusively for the reduced naproxen binding. This has been shown by studies with serum to which bilirubin was added in vitro. The hypothetical plasma concentration at the time zero and the half-lives of naproxen were not altered in patients with hepatocellular or obstructive icterus in comparison with healthy subjects. This may possibly cause an increased pharmacologic effect of naproxen in icteric patients when the drug is administered in usual doses. For in this case the pharmacologically active unbound part of the drug must be increased.
在肝细胞性黄疸或梗阻性黄疸患者中，（+）-6-甲氧基-α-甲基-2-萘乙酸（萘普生）的血清蛋白结合率分别显著降低。血清胆红素浓度与萘普生的血清蛋白结合率之间存在显著的负相关。然而，胆红素并非萘普生结合率降低的唯一原因。体外添加胆红素的血清研究已证实了这一点。与健康受试者相比，肝细胞性黄疸或梗阻性黄疸患者中萘普生的零时血浆浓度和半衰期并未改变。当以常规剂量给药时，这可能会导致萘普生在黄疸患者中的药理作用增强。因为在这种情况下，药物的药理活性游离部分必然会增加。
