睾酮对大鼠雄性生殖器官中葡糖胺-6-磷酸合酶活性的调节作用。

Regulation by testosterone of the glucosamine-6-phosphate synthase activity in the male reproductive organs of rat.

作者信息

Rukmini V, Reddy P R

出版信息

Biochim Biophys Acta. 1980 Jul 15;630(4):559-63. doi: 10.1016/0304-4165(80)90010-0.

PMID:7190441

Abstract

Accessory reproductive organs of male rat were found to contain high activities of glucosamine-6-phosphate synthase (glucosaminephosphate isomerase (glutamine-forming), EC 5.3.1.19). Castration caused drastic reduction (75%) in the enzyme activity of ventral prostate. Testosterone propionate administration restored the enzyme activity while cortisol and estradiol-17 beta did not cause any effect. Cycloheximide blocked the stimulation caused by testosterone.

摘要

发现雄性大鼠的附属生殖器官含有高活性的葡糖胺-6-磷酸合酶（葡糖胺磷酸异构酶（谷氨酰胺形成），EC 5.3.1.19）。去势导致腹侧前列腺的酶活性急剧降低（75%）。丙酸睾酮给药可恢复酶活性，而皮质醇和雌二醇-17β则没有任何影响。放线菌酮可阻断睾酮引起的刺激作用。