Allen R M, Lane J D, Brauchi J T
Eur J Pharmacol. 1980 Jul 25;65(2-3):313-5. doi: 10.1016/0014-2999(80)90409-4.
In this report evidence is presented that amantadine hydrochloride greatly reduced the development of dopaminergic receptor hypersensitivity in the striatum, which normally results following chronic haloperidol administration using both a stereotyped behavior bioassay and a [3H]spiroperidol receptor binding assay. Amantadine prophylaxis reduced maximal ligand binding to near control levels and also significantly reduced apomorphine induced stereotypy. These results clearly demonstrate that amantadine greatly reduced haloperidol-induced striatal dopamine receptor hypersensitivity and support the hypothesis that amantadine given concurrently with neuroleptic agents might serve to prevent the development of human tardive dyskinesia.
本报告提供的证据表明，盐酸金刚烷胺能显著降低纹状体中多巴胺能受体超敏反应的发生，这种超敏反应通常在长期使用氟哌啶醇后出现，采用了刻板行为生物测定法和[3H]螺哌啶受体结合测定法。金刚烷胺预防性给药可使最大配体结合降低至接近对照水平，并显著降低阿扑吗啡诱导的刻板行为。这些结果清楚地表明，金刚烷胺能显著降低氟哌啶醇诱导的纹状体多巴胺受体超敏反应，并支持这样一种假说，即与抗精神病药物同时给予金刚烷胺可能有助于预防人类迟发性运动障碍的发生。
