Kromberg J, Bernstein R, Jenkins T, Bernstein J, Goudie E G, Sneider P
S Afr Med J. 1980 Jun 21;57(25):1031-9.
During a 2-year period 438 mid-trimester amniocenteses were performed on women at risk of producing an abnormal infant. The commonest indications were advanced maternal age (61% of cases), neural tube defects (18%) and Down syndrome (11%). A 92,5% follow-up revealed a spontaneous abortion rate of 3% (1,5% if abortions within 8 days of the procedure were considered). Premature birth occurred in 4,4% of cases, neonatal death or stillbirth in 0,7%, and birth defects which were detectable by amniocentesis in 2%. Abnormalities were detected in 4,9% of cases, so that 95,1% of the patients were reasured by the results obtained. No defects diagnosable by amniocentesis were missed.
在两年时间里，对有生育异常婴儿风险的女性进行了438次孕中期羊膜穿刺术。最常见的指征是孕妇年龄偏大（占病例的61%）、神经管缺陷（18%）和唐氏综合征（11%）。92.5%的随访显示自然流产率为3%（如果将术后8天内的流产考虑在内则为1.5%）。早产发生在4.4%的病例中，新生儿死亡或死产在0.7%，通过羊膜穿刺术可检测到的出生缺陷在2%。在4.9%的病例中检测到异常，因此95.1%的患者对所获结果感到放心。没有遗漏通过羊膜穿刺术可诊断出的缺陷。
