Belousova A K, Gerasimova G K
Antibiot Chemother (1971). 1980;28:48-52. doi: 10.1159/000386059.
The metabolism of murine tumors sensitive and resistant to 6-theopurines and 5-fluorouracil (5-FU) was studied. A positive correlation between the tumor sensitivity to thiopurines, the level of hypoxanthine-guanine-phosphoribosyl transferase and the rates of the antimetabolite incorporation into RNA and DNA was shown. The sensitivity of tumors to 5-FU correlated with the rates of pyrimidine nucleosides and antimetabolite uptake and the time of retention of labeled 5-FU in RNA. The activites of orotate-phosphoribosyl transferase, uridine kinase, the degree of thymidylate synthetase inhibition of 5-FU and ratio of the de novo to salvage pathways of thymidylate biosynthesis are also important.
对6-硫代嘌呤和5-氟尿嘧啶（5-FU）敏感及耐药的小鼠肿瘤的代谢情况进行了研究。结果表明，肿瘤对硫代嘌呤的敏感性、次黄嘌呤-鸟嘌呤-磷酸核糖转移酶水平与抗代谢物掺入RNA和DNA的速率之间呈正相关。肿瘤对5-FU的敏感性与嘧啶核苷和抗代谢物的摄取速率以及标记的5-FU在RNA中的保留时间相关。乳清酸-磷酸核糖转移酶、尿苷激酶的活性、5-FU对胸苷酸合成酶的抑制程度以及胸苷酸生物合成的从头合成途径与补救途径的比例也很重要。
