化学致癌作用的生物化学方面
Biochemical aspects of chemical carcinogenesis.
作者信息
Gielen J E
出版信息
Bull Cancer. 1978;65(3):249-54.
PMID:719180
Abstract
This article briefly outlines three major biochemical problems in relation to the presence of chemical carcinogens in mammalian cells: (a) the enzymatic systems responsible for the chemical carcinogen metabolism; (b) the nature of the reactive metabolites and (c) the cellular target(s). References and examples are only given for the field of the polycyclic aromatic hydrocarbons.
摘要
本文简要概述了与哺乳动物细胞中化学致癌物的存在相关的三个主要生化问题
（a）负责化学致癌物代谢的酶系统；（b）反应性代谢产物的性质；以及（c）细胞靶点。仅针对多环芳烃领域给出了参考文献和示例。
相似文献
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Biochemical aspects of chemical carcinogenesis.化学致癌作用的生物化学方面
Bull Cancer. 1978;65(3):249-54.
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Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis.多环芳烃的代谢：在致癌作用中的病因学作用。
Pharmacol Rev. 1982 Jun;34(2):189-222.
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Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.个体人类细胞色素P-450酶在苯并(a)芘、7,8-二羟基-7,8-二氢苯并(a)芘及其他多环芳烃二氢二醇衍生物生物活化中的作用。
Cancer Res. 1989 Nov 15;49(22):6304-12.
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Specificity of DNA damage in chemical carcinogenesis.化学致癌作用中DNA损伤的特异性。
IARC Sci Publ. 1980(27):41-54.
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Carcinogen metabolism in human tissues and cells.人体组织和细胞中的致癌物代谢
Drug Metab Rev. 1982;13(4):603-46. doi: 10.3109/03602538209011089.
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Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.关于人类和实验动物化学致癌作用的一些当前观点：主席致辞
Cancer Res. 1978 Jun;38(6):1479-96.
9
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Binding of polycyclic aromatic hydrocarbons to DNA: comparison with mutagenesis and tumorigenesis.多环芳烃与DNA的结合：与诱变和肿瘤发生的比较。
J Toxicol Environ Health. 1980 Sep-Nov;6(5-6):1009-20. doi: 10.1080/15287398009529923.
引用本文的文献
1
Ontogenetic variation in rat liver, lung and kidney monooxygenase induction by low doses of benzo(A)pyrene and cigarette-smoke condensate.低剂量苯并（A）芘和香烟烟雾冷凝物对大鼠肝脏、肺和肾脏单加氧酶诱导作用的个体发育变化。
Br J Cancer. 1981 Dec;44(6):902-10. doi: 10.1038/bjc.1981.290.
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