8-甲氧基补骨脂素/紫外线A在细胞培养中的致突变性和致癌性。
Mutagenicity and carcinogenicity of 8-MOP/UVA in cell cultures.
作者信息
Burger P M, Simons J W
出版信息
Bull Cancer. 1978;65(3):281-2.
PMID:719181
Abstract
HGPRT-deficient mutants of chinese hamster cells and human skin fibroblasts are selected with 6-thioguanine after treatment with the combination 8-MOP and UVA. Calculation based on this study indicate that 1.7 X 10(-5) mutants will be induced in the epidermis per session of PUVA therapy. Induction of cell-transformation was observed in C3H and 3T3 mouse cells.
摘要
在用8-甲氧基补骨脂素（8-MOP）和紫外线A（UVA）联合处理后，用6-硫鸟嘌呤筛选中国仓鼠细胞和人皮肤成纤维细胞的次黄嘌呤-鸟嘌呤磷酸核糖转移酶（HGPRT）缺陷型突变体。基于该研究的计算表明，每次补骨脂素加长波紫外线（PUVA）治疗会在表皮中诱导产生1.7×10⁻⁵个突变体。在C3H和3T3小鼠细胞中观察到了细胞转化的诱导。
Zotero 插件