Wein A J, Malloy T R, Shofer F, Raezer D M
J Urol. 1980 Sep;124(3):397-9. doi: 10.1016/s0022-5347(17)55465-8.
A 5 mg. subcutaneous dose of bethanechol chloride was given to 12 women with residual urine volumes equal to or greater than 20 per cent of bladder capacity but no evidence of neurologic disease, or anatomic or functional outlet obstruction and to 27 normal women wtih approximately the same mean age. The cystometric and some profilometric parameters did change, indicating that the drug was pharmacologically active. No improvement in voiding function was noted, as judged by residual urine volume and flow rate measurements. These results raise significant questions regarding the contemporary use of this drug, especially in the currently recommended oral dosages.
对12名残余尿量等于或大于膀胱容量20%但无神经疾病证据、无解剖学或功能性出口梗阻的女性，以及27名平均年龄大致相同的正常女性，皮下注射5毫克氯贝胆碱。膀胱测压和一些压力测定参数确实发生了变化，表明该药物具有药理活性。根据残余尿量和流速测量判断，排尿功能没有改善。这些结果对该药物的当代使用，尤其是当前推荐的口服剂量，提出了重大疑问。
