Koval'skaia S Ia, Ozeretskovskiĭ N A, Veĭsfeĭler O Iu, Bulatova A I
Zh Mikrobiol Epidemiol Immunobiol. 1980 Jul(7):54-8.
The possibility of using pharmacological tests to determine side effects produced by adsorbed DPT vaccine and chemical typhoid vaccine was studied. Both vaccines were shown to be capable of prolonging sleep induced by hexenal or thiopental in experimental animals. The following difference in the action of these two preparations was revealed on the model of "chemical convulsions" induced by the injection of thiosemicarbazide: while immunization with DPT vaccine acitivated thiosemicarbazide-induced convulsive syndrome in mice, no such stimulating effect was observed after the injection of typhoid, vaccine. The study of pharmacological effects allowed to evaluate some aspects of the side effects producted by prophylactic preparations.
研究了使用药理学试验来确定吸附白喉、百日咳、破伤风疫苗（DPT疫苗）和化学伤寒疫苗产生的副作用的可能性。在实验动物中，这两种疫苗均显示出能够延长己烯醛或硫喷妥钠诱导的睡眠时间。在注射氨基硫脲诱导的“化学惊厥”模型上，揭示了这两种制剂作用的以下差异：用DPT疫苗免疫可激活小鼠中氨基硫脲诱导的惊厥综合征，而注射伤寒疫苗后未观察到这种刺激作用。对药理作用的研究有助于评估预防性制剂产生的副作用的某些方面。
