Knecht E A, Toraason M A, Wright G L
Am J Physiol. 1980 Nov;239(5):R470-5. doi: 10.1152/ajpregu.1980.239.5.R470.
Thermoregulatory ability of female rats was examined before pregnancy, during gestation, and during lactation. Thermoregulatory pattern, colonic temperature, evaporative water loss, and survival time were monitored during terminal heating (39.5 +/- 0.9 degrees C) designed to allow prolonged survival (3-4 h) with a sustained thermoregulatory effort. Results confirmed our previously reported observation of decreased thermoregulatory ability in lactating dams, with evidence suggesting thermoregulatory impairment during late gestation. Lactating dams displayed a type III thermoregulatory pattern, and established a rate of evaporative water loss effective for thermostasis at an elevated colonic temperature. However, survival time was significantly decreased compared to nonreproducing females. In contrast, prior heat acclimation tended to increase the survival time of lactating dams. It was concluded that the reduction in thermoregulatory ability observed in lactating dams was related to their inability to maintain a rate of evaporative water loss effective for thermostasis at an elevated colonic temperature.
在怀孕前、妊娠期和哺乳期对雌性大鼠的体温调节能力进行了检查。在旨在通过持续的体温调节努力实现延长存活时间（3 - 4小时）的终末加热（39.5±0.9摄氏度）过程中，监测体温调节模式、结肠温度、蒸发失水量和存活时间。结果证实了我们之前报道的哺乳期母鼠体温调节能力下降的观察结果，有证据表明在妊娠后期存在体温调节受损。哺乳期母鼠表现出III型体温调节模式，并在升高的结肠温度下建立了对体温恒定有效的蒸发失水量速率。然而，与未繁殖的雌性相比，存活时间显著缩短。相比之下，预先进行热适应倾向于增加哺乳期母鼠的存活时间。得出的结论是，哺乳期母鼠体温调节能力的降低与其在升高的结肠温度下无法维持对体温恒定有效的蒸发失水量速率有关。
