Tissue distribution of 14C-indoprofen in the rat.

The tissue distribution of 14C-labelled 2-[p-(1-oxo-2-isoindolinyl)phenyl)propionic acid (indoprofen) after i.v. injection was studied in male and pregnant rats by whole-body autoradiography. Distribution was characterized by a rapid localization in the liver, kidneys and lungs. A significant amount of radioactivity found in the intestinal contents suggested biliary excretion. There was no indication of retention of the drug in the brain. In pregnant rats, radioactivity crossed the blood-placenta barrier to a moderate extent and low concentrations were found in foetuses.