Merkle H P, Higuchi W I
Arzneimittelforschung. 1980;30(11):1841-6.
This study presents in vitro techniques to follow the adsorption and subsequent surface proliferation of Streptococcus mutans on hydroxyapatite surfaces leading to artificial plaque. Inhibition of proliferation as well as extracellular dextrane formation can be achieved by pretreatments of the hydroxyapatite surface with aqueous solutions of sodium ricinoleate. The antibacterial activity is restricted to an antibacterial microenvironment adjacent to the hydroxyapatite surface.
本研究介绍了体外技术，以跟踪变形链球菌在羟基磷灰石表面的吸附及随后的表面增殖，从而形成人工菌斑。通过用蓖麻油酸钠水溶液对羟基磷灰石表面进行预处理，可以抑制增殖以及细胞外葡聚糖的形成。抗菌活性仅限于与羟基磷灰石表面相邻的抗菌微环境。
