曲匹地尔对离体犬冠状动脉舒张作用的分析。
Analysis of relaxant effects of trapidil in isolated dog coronary artery.
作者信息
Sakanashi M, Yoshikawa Y, Kondoh G, Fukai R, Hirata A, Higuchi M
出版信息
Arzneimittelforschung. 1980;30(11):1871-4.
Effects of 7-diethylamino-5-methyl-s-triazolo [1,5-a]pyrimidine (trapidil, Rocornal) on dog coronary arteries were investigated in vitro. Trapidil produced dose-dependent relaxations of isolated arteries which were contracted with potassium or prostaglandins F2 alpha. These effects of trapidil were not affected by atropine and propranolol. 5-Hydroxytryptamine (5-HT) and phenylephrine dose-dependently increased the tension of isolated coronary arteries. Trapidil could inhibit these effects of 5-HT or phenylephrine. The results indicate that trapidil has not a muscarinic action and an adrenergic beta-receptor stimulating action, but it has a 5-HT receptor and an adrenergic alpha-receptor blocking action.
在体外研究了7-二乙氨基-5-甲基-s-三唑并[1,5-a]嘧啶（曲匹地尔，乐可安）对犬冠状动脉的作用。曲匹地尔对用钾或前列腺素F2α收缩的离体动脉产生剂量依赖性舒张作用。曲匹地尔的这些作用不受阿托品和普萘洛尔的影响。5-羟色胺（5-HT）和去氧肾上腺素剂量依赖性地增加离体冠状动脉的张力。曲匹地尔可抑制5-HT或去氧肾上腺素的这些作用。结果表明，曲匹地尔不具有毒蕈碱样作用和肾上腺素能β受体激动作用，但具有5-HT受体阻断作用和肾上腺素能α受体阻断作用。
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