D-青霉胺（DPA）对人淋巴细胞作用机制的研究（作者译）
[Studies on the mechanism of action of D-penicillamine (DPA) on human lymphocytes (author's transl)].
作者信息
Feickert H J, Schumacher K
出版信息
Arzneimittelforschung. 1980;30(9):1480-3.
PMID:7193012
Abstract
From in vitro investigations we have evidence that the inhibition by D-penicillamine (DPA) of lymphocyte transformation is caused by an inhibitory effect on the cell membrane. This inhibition is reversible by washing the lymphocytes. Our results were confirmed by kinetic studies in lymphocyte cultures, using mitogens and DPA. The amount of DPA-molecules bound to lymphocytes was determined with about 2.5 x 10(6) molecules/lymphocyte.
摘要
从体外研究中我们获得证据，表明D-青霉胺（DPA）对淋巴细胞转化的抑制作用是由对细胞膜的抑制效应引起的。通过洗涤淋巴细胞，这种抑制作用是可逆的。我们的结果通过在淋巴细胞培养物中使用有丝分裂原和DPA进行的动力学研究得到了证实。与淋巴细胞结合的DPA分子数量测定为约2.5×10⁶个分子/淋巴细胞。
Zotero 插件