Zimmermann A
Urologe A. 1980 Nov;19(6):391-6.
DNA-estimations, done by flow-through-cytophotometry, were performed in 18 malignant tumors of testis. Aneuploid stemlines which are specific for cancers were found in 17 cases. The only exception was a so called "occult seminoma". It showed only a small difference between the stem-line of tumor and normal cells of testis. So, by using DNA-estimation, it was possible to make a correct diagnosis all 18 patients, suffering from tumor of the testis. The aneuploid stem-lines of seminomas did not differ from those of other cancers. The type of proliferative behavior seems to be a criterion for prognosis. Lymphatic nodes with and without formation of metastases very clearly showed differences in the DNA-content of their nuclei.
通过流动式细胞光度法对18例睾丸恶性肿瘤进行了DNA测定。在17例病例中发现了癌症特有的非整倍体干细胞系。唯一的例外是一种所谓的“隐匿性精原细胞瘤”。它在肿瘤干细胞系与睾丸正常细胞之间仅表现出微小差异。因此，通过DNA测定，有可能对所有18例睾丸肿瘤患者做出正确诊断。精原细胞瘤的非整倍体干细胞系与其他癌症的并无差异。增殖行为类型似乎是预后的一个标准。有转移和无转移形成的淋巴结在其细胞核DNA含量上表现出非常明显的差异。
