铂（II）胺在大鼠中表现出的一种特殊毒性：腹腔注射后胃扩张。
A peculiar toxicity manifested by platinum(II)amines in rats: gastric distension after intraperitoneal administration.
作者信息
Roos I A, Fairlie D P, Whitehouse M W
出版信息
Chem Biol Interact. 1981 Apr;35(1):111-7. doi: 10.1016/0009-2797(81)90066-1.
PMID:7193534
Abstract
Metoclopramide i.p. reduces the gastric distension consistently seen in rats given cisplatin i.p. at effective immunosuppressant doses (6 mg/kg). Many other immunosuppressant/oncolytic platinum amines also engendered gastric distension but certain dimers and 1,2-cyclohexanediaminoplatinum (II) compounds did not. This phenomenon appears to be due to paralysis of gastric emptying (without appetite suppression).
摘要
腹腔注射甲氧氯普胺可持续减轻腹腔注射有效免疫抑制剂量（6毫克/千克）顺铂的大鼠所出现的胃扩张。许多其他免疫抑制剂/溶瘤铂胺也会引起胃扩张，但某些二聚体和1,2 - 环己二胺铂（II）化合物则不会。这种现象似乎是由于胃排空麻痹（无食欲抑制）所致。
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