Rister M, Horatz M
Klin Padiatr. 1981 Jan;193(1):46-9. doi: 10.1055/s-2008-1034428.
Granulocyte adherence to endothelial surfaces associated with their chemotactic property enables these cells to leave the peripheral blood and to migrate into the tissue. This study was performed to investigate the effect of bacterial and viral infections as well as various kinds of therapies on these leukocyte functions. The adherence of control granulocytes to nylon fibers was 70%. In contrast to viral infections bacterial infections increased the adherence to 91%. Following the treatment with high dose methotrexate or vincristine the adherence was reduced to 20%. This granulocyte function defect was evident up to 14 days after the high dose methotrexate infusion. An age dependency of granulocyte adherence was not observed. In addition, viral infections as well as cytostatic therapy did not effect granulozyte chemotaxis. But bacterial infections and various defined phagocytic defects impaired the granulocyte chemotactic activity.
粒细胞对内皮表面的黏附及其趋化特性使这些细胞能够离开外周血并迁移到组织中。本研究旨在调查细菌和病毒感染以及各种治疗方法对这些白细胞功能的影响。对照粒细胞对尼龙纤维的黏附率为70%。与病毒感染相反，细菌感染使黏附率增加到91%。用高剂量甲氨蝶呤或长春新碱治疗后，黏附率降至20%。这种粒细胞功能缺陷在高剂量甲氨蝶呤输注后长达14天仍很明显。未观察到粒细胞黏附的年龄依赖性。此外，病毒感染以及细胞抑制疗法不影响粒细胞趋化性。但细菌感染和各种明确的吞噬缺陷会损害粒细胞趋化活性。
