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Effect of dihydroxydibutylether (DHBE) on bile flow and composition in rats with ethynylestradiol-induced cholestasis.

作者信息

Podda M, Zuin M, Dioguardi M L, Festorazzi S, Di Padova C

出版信息

Arzneimittelforschung. 1980;30(12):2126-8.

PMID:7194073
Abstract

Administration of dihydroxydibutylether (DHBE, Dis-Cinil) to rats with ethynylestradiol(EE)-induced cholestasis provoked an increase in bile flow and output of bile acids and phospholipids. Since EE-induced cholestasis is related to the condition observed in humans, a clinical trial of DHBE in cholestatic syndromes seems worthwhile.

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