Podda M, Zuin M, Dioguardi M L, Festorazzi S, Di Padova C
Arzneimittelforschung. 1980;30(12):2126-8.
Administration of dihydroxydibutylether (DHBE, Dis-Cinil) to rats with ethynylestradiol(EE)-induced cholestasis provoked an increase in bile flow and output of bile acids and phospholipids. Since EE-induced cholestasis is related to the condition observed in humans, a clinical trial of DHBE in cholestatic syndromes seems worthwhile.
