Fischer J H
Arzneimittelforschung. 1980;30(12):2132-4.
In Wistar rats thermocontrolled normothermic ischemia of the whole body was induced 20 min after i.p. injection of 300 mg piridoxilate (Glyco-6) per kg body weight or Ringer's solution in a control group. Piridoxilate pretreatment did not influence the amount of total adenine nucleotide loss in 30 min of normothermic ischemia of forebrain, skeletal muscle, liver or kidney but resulted in a significantly higher loss in myocardium and lung. A positive effect on the conversation of energy rich substances was found only in the skeletal muscle (creatine phosphate content). Significant effects on substrates of glycolysis were found only in myocardium and lung but in the myocardium also a higher accumulation of lactate occurred.
在Wistar大鼠中，腹腔注射每千克体重300毫克吡哆醛酸（Glyco-6）20分钟后或在对照组注射林格氏液后，诱导全身温度控制的正常体温缺血。吡哆醛酸预处理对前脑、骨骼肌、肝脏或肾脏正常体温缺血30分钟时总腺嘌呤核苷酸的损失量没有影响，但导致心肌和肺中的损失显著更高。仅在骨骼肌中发现对富含能量物质的转化有积极作用（磷酸肌酸含量）。仅在心肌和肺中发现对糖酵解底物有显著影响，但在心肌中也出现了更高的乳酸积累。
