老年痴呆症中胆碱能异常与老年斑及心理测试分数的相关性
Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.
作者信息
Perry E K, Tomlinson B E, Blessed G, Bergmann K, Gibson P H, Perry R H
出版信息
Br Med J. 1978 Nov 25;2(6150):1457-9. doi: 10.1136/bmj.2.6150.1457.
Abstract
Necropsy brain tissue from normal (control) patients and patients with depression and dementia was examined for activities of various cholinergic components, and these related to the degree of senile plaque formation and extent of intellectual impairment. Choline acetyltransferase and acetylcholinesterase activities decreased significantly as the mean plaque count rose, and in depressed and demented subjects the reduction in choline acetyltransferase activity correlated with the extent of intellectual impairment as measured by a memory information test; muscarinic cholinergic receptor binding activity remained unchanged with increasing senile plaque formation but butyrylcholinesterase activity increased. The results suggest a close relation between changes in the cholinergic system and Alzheimer's dementia, but the precise role of the system in this disease remains to be elucidated.
摘要
对正常（对照）患者以及患有抑郁症和痴呆症患者的尸检脑组织进行了各种胆碱能成分活性的检测，这些活性与老年斑形成程度和智力损害程度相关。随着平均斑块计数的增加，胆碱乙酰转移酶和乙酰胆碱酯酶活性显著降低，并且在抑郁和痴呆受试者中，胆碱乙酰转移酶活性的降低与通过记忆信息测试所测量的智力损害程度相关；毒蕈碱胆碱能受体结合活性随着老年斑形成的增加而保持不变，但丁酰胆碱酯酶活性增加。结果表明胆碱能系统的变化与阿尔茨海默病痴呆症之间存在密切关系，但该系统在这种疾病中的精确作用仍有待阐明。
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