An improved version of the steric difference method.
作者信息
Motoc I
出版信息
Arzneimittelforschung. 1981;31(2):290-3.
PMID:7194643
Abstract
The steric difference (SD) method was developed to account for steric effects in the QSAR framework. The improved version (SD*) here reported takes into account the volume of different atoms, using some results recently obtained. The SD* method is applied to some concrete cases, and the obtained equations are compared with the results obtained from other methods. Finally, the physical significance of some steric parameters used in QSAR is discussed.
摘要
相似文献
1
An improved version of the steric difference method.
Arzneimittelforschung. 1981;31(2):290-3.
2
Molecular connectivity and steric parameters.分子连接性和空间参数。
J Pharm Sci. 1977 Sep;66(9):1352-4. doi: 10.1002/jps.2600660943.
3
Steric and lipophobic components of the hydrophobic fragmental constant.疏水片段常数的空间位阻和亲脂性成分。
Arzneimittelforschung. 1981;31(7):1053-8.
4
OSAR in a series of muscarinic agents. Note III--Alkyltrimethylammonium salts, ethers and esters of choline.
Farmaco Sci. 1981 Sep;36(9):749-64.
5
[Application of Verloop parameters. Comparison with other steric parameters and problems of choice of parameter].
Farmaco Sci. 1980 Feb;35(2):89-109.
6
The roles of hetero atoms in solvolytic reactions. III. Some evidence for preference of intramolecular catalysis by nitrogen in hydrolysis of tertiary alkyl esters.
Chem Pharm Bull (Tokyo). 1974 Aug;22(8):1706-10. doi: 10.1248/cpb.22.1706.
7
[Relations between chemical structure, physico-chemical reactivity and local anesthetic activity of some procaine isosteres. 29].
Arzneimittelforschung. 1972 Jun;22(6):1071-84.
8
Kinetic steric factors and connectivity indices.
J Pharm Sci. 1984 Oct;73(10):1472-7. doi: 10.1002/jps.2600731038.
9
10
QSAR studies on psychotomimetic phenylalkylamines.关于拟精神病苯基烷基胺的定量构效关系研究。
Arzneimittelforschung. 1983;33(8):1089-90.
Zotero 插件