饥饿大鼠中阿扑吗啡诱导刻板行为的药代动力学研究。
Pharmacokinetic study of apomorphine-induced stereotypy in food deprived rats.
作者信息
Watanabe H, Nakano S, Ogawa N
出版信息
Pharmacol Biochem Behav. 1981 Apr;14(4):493-6. doi: 10.1016/0091-3057(81)90308-7.
The relationship between the effect of food deprivation on apomorphine-induced stereotypy and the plasma apomorphine concentration in rats was studied. Male Wistar rats, allowed to have free access to food and water on deprived of food for 48 hr, were injected subcutaneously with apomorphine hydrochloride (10 mg/kg). Food deprivation was liable to potentiate the apomorphine-induced stereotypy in the early stage after dosing. Higher plasma apomorphine concentrations were found in the food deprived rats at this observation period. The potentiation of apomorphine-induced stereotypy following food deprivation can in part be explained by the pharmacokinetics changes. The exact mechanism of the effect of food deprivation on apomorphine kinetics is not clear at present.
研究了食物剥夺对阿扑吗啡诱导的刻板行为的影响与大鼠血浆阿扑吗啡浓度之间的关系。雄性Wistar大鼠，在自由获取食物和水的情况下被剥夺食物48小时，然后皮下注射盐酸阿扑吗啡（10毫克/千克）。食物剥夺易于在给药后的早期增强阿扑吗啡诱导的刻板行为。在此观察期内，食物剥夺的大鼠血浆阿扑吗啡浓度较高。食物剥夺后阿扑吗啡诱导的刻板行为的增强部分可由药代动力学变化来解释。目前尚不清楚食物剥夺对阿扑吗啡动力学影响的确切机制。
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