McMahon J E
Arzneimittelforschung. 1981;31(3a):592-4.
2-Cyclo-hexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one (praziquantel, EMBAY 8440, Biltricide), a new schistosomicide, given to subjects with Schistosoma mansoni infections in a single oral dose of 40 mg/kg or 50 mg/kg in 2 divided doses resulted in probable cure rates at 6 months of 74% and 88.1%, respectively. The corresponding reduction in egg excretion of the non-cured cases was 96.9% and 97.3%. Side effects were not severe but included urticaria, loose bowel motions, abdominal pain and sleepiness.
2-环己基羰基-1,2,3,6,7,11b-六氢-4H-吡嗪并[2,1-a]异喹啉-4-酮（吡喹酮，EMBAY 8440，Biltricide），一种新型抗血吸虫药，以40mg/kg的单次口服剂量或50mg/kg分2次给药于曼氏血吸虫感染患者，6个月时的可能治愈率分别为74%和88.1%。未治愈病例的虫卵排泄相应减少率分别为96.9%和97.3%。副作用不严重，但包括荨麻疹、腹泻、腹痛和嗜睡。
