[人正常及增生前列腺中5α-雄甾烷-3β,17β-二醇的7-α-羟基化作用]
[7-alpha-Hydroxylation of 5 alpha-androstane-3 beta, 17 beta-diol in human normal and hyperplastic prostates].
作者信息
Morfin R, Floch H
出版信息
C R Acad Hebd Seances Acad Sci D. 1977 Sep 12;285(4):373-6.
PMID:71955
Abstract
Incubation of 4-14C-5 alpha-androstane-3 beta, 17 beta-diol with human normal and hyperplastic prostate minces led to the NADPH-dependent production of a major polar radiometabolite which was identified as 5 alpha-androstane-3 beta, 7 alpha, 17 beta-triol and proved the presence of a 3 beta-hydroxysteroid-7 alpha-hydroxylase in prostate. Such evidences may bring new leads for the study of the mechanisms of androgenic steroid action in the prostate gland.
摘要
将4-¹⁴C-5α-雄甾烷-3β,17β-二醇与人正常及增生前列腺组织块一起孵育，导致产生一种主要的极性放射性代谢物，该代谢物经鉴定为5α-雄甾烷-3β,7α,17β-三醇，这证明前列腺中存在3β-羟基类固醇-7α-羟化酶。这些证据可能为研究雄激素类固醇在前列腺中的作用机制带来新的线索。
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