Crum C P, Richart R M, Fenoglio C M
Am J Surg Pathol. 1981 Jan;5(1):15-20.
Adenoacanthosis of the endometrium is a disorder characterized by glandular hyperplasia with squamous metaplasia. A clinicopathologic study was done of 10 cases, the majority of which were referred for consultation as atypical hyperplasia of adenoacanthoma. All of the patients were premenopausal and ranged in age from 19 to 45 years: they presented with abnormal bleeding or infertility. In four cases the adjacent endometrium was normal cycling endometrium; two were associated with chronic endometritis, and two were present within endometrial polyps. Three patients responded conservative therapy; in two others, hysterectomy disclosed no residual lesion. Although adenoacanthosis has certain morphologic features mimicking adenoacanthoma, it can be distinguished from this lesion by its growth pattern and cytologic features. Whether adenoacanthosis is a cancer precursor is unknown, but the potential reversibility of the lesion warrants conservative therapy, particularly in women of childbearing age.
子宫内膜腺棘皮病是一种以腺体增生伴鳞状化生为特征的疾病。对10例患者进行了临床病理研究，其中大多数患者因腺棘皮瘤非典型增生前来咨询。所有患者均处于绝经前，年龄在19至45岁之间，表现为异常出血或不孕。4例患者的相邻子宫内膜为正常周期性子宫内膜；2例与慢性子宫内膜炎相关，2例存在于子宫内膜息肉内。3例患者接受了保守治疗；另外2例患者行子宫切除术后未发现残留病变。尽管腺棘皮病具有某些模仿腺棘皮瘤的形态学特征，但可通过其生长模式和细胞学特征与该病变相鉴别。腺棘皮病是否为癌前病变尚不清楚，但该病变的潜在可逆性值得进行保守治疗，尤其是对育龄期女性。
