Darby B L, Streissguth A P, Smith D W
Neurobehav Toxicol Teratol. 1981 Summer;3(2):157-9.
Fetal Alcohol Syndrome (FAS) has been recognized as a serious developmental problem occurring in some offspring of alcoholic women. A broad range of intellectual deficits has been reported in children with FAS, but most of these children have been identified in early childhood, when developmental retardation is evident. However, FAS can be diagnosed from birth on the basis of growth deficiency and certain morphological characteristics, as well as a history of maternal alcoholism. Eight children, who were given a diagnosis of FAS at birth or within the first eight months of life and who were available for follow-up in 1980, constituted the sample for the present clinical study. These children, ranging in age from 14 months to 6-3/4 years on last follow-up were given age-appropriate developmental or IQ tests. The means IQ score of these eight children at last follow-up was 76 (range 40--107).
胎儿酒精综合征(FAS)已被确认为酗酒女性的部分后代中出现的一种严重发育问题。据报道,患有FAS的儿童存在广泛的智力缺陷,但这些儿童大多是在幼儿期被确诊的,此时发育迟缓很明显。然而,FAS可以根据生长发育不足、某些形态特征以及母亲酗酒史从出生时就进行诊断。八名在出生时或出生后八个月内被诊断为FAS且在1980年可供随访的儿童构成了本临床研究的样本。这些儿童在最后一次随访时年龄从14个月到6又3/4岁不等,接受了适合其年龄的发育或智商测试。这八名儿童在最后一次随访时的平均智商得分是76(范围为40 - 107)。