Fukuhara S, Rowley J D, Variakojis D
Cancer. 1978 Nov;42(5):2262-8. doi: 10.1002/1097-0142(197811)42:5<2262::aid-cncr2820420526>3.0.co;2-2.
Chromosomes from a patient with mycosis fungoides were examined in detail with banding techniques. Hyperdiploid cells from a lymph node had common anomalies of certain chromosomes which formed three similar clones. The abnormalities involved chromosomes No. 1, 2, 5, 8, 9, 10, 14, and 18, in addition to an unkwown small metacentric marker (M3). Although there were a number of mitotic cells in peripheral blood cultured both with and without PHA, none of the few cells with abnormal karyotypes was similar to the clonal cells of the lymph node. One of the abnormalities in the lymph node was a 14q rearrangement, which could be the result of a translocation of Nos. 8 and 14 involving a third chromosome, No. 2. An abnormality in the blood resulted from a translocation between the long arms of Nos. 1 and 14. These findings could be useful for studies in which mycosis fungoides is compared with the Sézary syndrome and other lymphoid malignancies.
运用显带技术对1例蕈样肉芽肿患者的染色体进行了详细检查。来自淋巴结的超二倍体细胞存在某些染色体的常见异常，形成了三个相似的克隆。除了一条未知的小中着丝粒标记染色体（M3）外，异常涉及1、2、5、8、9、10、14和18号染色体。尽管在添加和未添加植物血凝素（PHA）培养的外周血中都有许多有丝分裂细胞，但少数核型异常的细胞中没有一个与淋巴结的克隆细胞相似。淋巴结中的异常之一是14q重排，这可能是8号和14号染色体易位并涉及第三条染色体2号染色体的结果。血液中的异常是由1号和14号染色体长臂之间的易位导致的。这些发现可能有助于将蕈样肉芽肿与塞扎里综合征及其他淋巴系统恶性肿瘤进行比较的研究。
