Thorns C J, Boughton E
Res Vet Sci. 1980 Nov;29(3):328-32.
The mouse mastitis model was used to examine strains of Mycoplasma bovis. Strains that had been passaged in liquid medium more than 60 times were markedly less virulent than the same or different strains with fewer passages. Whereas the low passage strains produced a systemic response in some mice and severe pathological and histopathological changes in the mammary glands of all, the high passage strains produced only minor histopathological changes.
采用小鼠乳腺炎模型来检测牛支原体菌株。在液体培养基中传代超过60次的菌株，其毒力明显低于传代次数较少的相同或不同菌株。低传代菌株在一些小鼠中引发全身反应，并在所有小鼠的乳腺中产生严重的病理和组织病理学变化，而高传代菌株仅产生轻微的组织病理学变化。
