Le Bars J
Ann Rech Vet. 1980;11(3):321-6.
Main parameters of penicillic acid (P.A.) production by P. verrucosum var. cyclopium were investigated: substrate nature, water content (H: 22-70%), temperature (5-30% degrees C), confined air and incubation delay. 6100, 2820, 1832, 39 and 0.8 mg/kg were the maximal yields obtained in corn, barley, straw, colza and soya. Toxinogenesis rate was greatly enhanced in crushed corn. Maximal yields in corn increased exponentially with H; production and disappearance rates of the free toxin were an increasing function of H and temperature; so, low temperatures may lead to a high accumulation of P.A. within several months. In a confined environment, P.A. concentration was limited for H greater than or equal to 40%; but accession of air induced an accelerated P.A. biogenesis. Maximal yield of P.A. (8000 mg/kg) was obtained in corn with 60% water content, within one week at 25 degrees C.
研究了疣孢青霉变种环孢青霉产生青霉酸（P.A.）的主要参数：底物性质、含水量（H：22 - 70%）、温度（5 - 30℃）、密闭空气和培养延迟。在玉米、大麦、秸秆、油菜籽和大豆中获得的最大产量分别为6100、2820、1832、39和0.8毫克/千克。破碎玉米中的毒素生成率大大提高。玉米中的最大产量随含水量呈指数增加；游离毒素的产生和消失速率是含水量和温度的增函数；因此，低温可能导致几个月内青霉酸大量积累。在密闭环境中，当含水量大于或等于40%时，青霉酸浓度受到限制；但通入空气会加速青霉酸的生物合成。在25℃下，含水量为60%的玉米在一周内可获得青霉酸的最大产量（8000毫克/千克）。
