Schaffler K, Hörmann E, Arnold H
Arzneimittelforschung. 1981;31(6):1032-5.
A pilot study of a double-blind crossover design was carried out in four healthy male volunteers. 3,5,5-Trimethylcyclohexyl mandelate (cyclandelate, Cyclospasmol) 800 mg b.d. was compared with placebo using two-week treatment periods separated by a wash-out-period. Under hypoxic conditions (11.5% O2) the volunteers were asked to perform a series of tests including a computer-assisted oculodynamic test (ODT) after one dosage and after fourteen days' treatment with both cyclandelate or placebo. ODT is a very sensitive test which is independent of learning or motivation. Certain cardiovascular and respiratory parameters were simultaneously recorded during the test periods. The results showed that cyclandelate protected the volunteers against the effects of hypoxia. The results after two weeks' treatment were more definite than those after the first dose, suggesting that cyclandelate acted centrally on cerebral metabolism rather than through a direct cerebrovascular effect.
在四名健康男性志愿者中进行了一项双盲交叉设计的初步研究。将3,5,5-三甲基环己基扁桃酸酯（环扁桃酯，Cyclospasmol）每日两次，每次800毫克与安慰剂进行比较，治疗期为两周，中间有洗脱期。在低氧条件下（氧气含量11.5%），要求志愿者在服用一次剂量以及用环扁桃酯或安慰剂治疗十四天后进行一系列测试，包括计算机辅助眼动力测试（ODT）。ODT是一项非常敏感的测试，与学习或动机无关。在测试期间同时记录某些心血管和呼吸参数。结果表明，环扁桃酯可保护志愿者免受低氧影响。两周治疗后的结果比首次给药后更明确，这表明环扁桃酯对大脑代谢起中枢作用，而非通过直接的脑血管效应起作用。
