[GABA-ergic correlates of aggression and intraspecies sociability of mice subjected to isolation].

Experiments on isolated mice (CC57W males) have demonstrated that GABA antagonists (bicuculline, picrotoxin, thiosemicarbazide) increase the desocializing effects of isolation (enhance aggression and reduce intraspecies sociability), while GABA-positive drugs (muscimol, gamma-acetylenic GABA) within a certain dosage range diminish aggression and favour a temporary recovery of sociability. It is suggested that GABA deficiency in the CNS of isolated mice is a pathogenetic link responsible for the pathological behavior -- superaggression and hyper-reactivity.