Poshivalov V P
Biull Eksp Biol Med. 1981 May;91(5):584-7.
Experiments on isolated mice (CC57W males) have demonstrated that GABA antagonists (bicuculline, picrotoxin, thiosemicarbazide) increase the desocializing effects of isolation (enhance aggression and reduce intraspecies sociability), while GABA-positive drugs (muscimol, gamma-acetylenic GABA) within a certain dosage range diminish aggression and favour a temporary recovery of sociability. It is suggested that GABA deficiency in the CNS of isolated mice is a pathogenetic link responsible for the pathological behavior -- superaggression and hyper-reactivity.
对隔离的小鼠（CC57W雄性）进行的实验表明，GABA拮抗剂（荷包牡丹碱、印防己毒素、氨基硫脲）会增强隔离的去社会化作用（增强攻击性并降低种内社交性），而在一定剂量范围内的GABA阳性药物（蝇蕈醇、γ-乙炔基GABA）会减少攻击性并有利于社交性的暂时恢复。有人提出，隔离小鼠中枢神经系统中的GABA缺乏是导致病理行为——过度攻击性和高反应性的致病环节。
