Miceli J N, Olson W A, Cohen S N
Dev Pharmacol Ther. 1981;2(4):235-9.
The elimination of isoniazid was followed in 2 newborn infants who had received the drug transplacentally, and in 1 of the mothers. The half-time for serum elimination for mother No. 1, babies No. 1 and 2 were calculated as 3.0, 7.8 and 19.8 h, respectively. Near equality existed between maternal and newborn serum isoniazid concentrations. Additional studies are required to determine the acetylation capacity of newborns.
对2名经胎盘接受异烟肼治疗的新生儿以及1名母亲进行了异烟肼消除情况的跟踪研究。计算得出1号母亲、1号婴儿和2号婴儿血清消除的半衰期分别为3.0小时、7.8小时和19.8小时。母亲和新生儿血清中的异烟肼浓度几乎相等。需要进行更多研究以确定新生儿的乙酰化能力。
