大鼠脑某些离散核团中谷氨酸脱羧酶活性的昼夜变化。

The diurnal variations of glutamic acid decarboxylase activity in some discrete nuclei of rat brain.

作者信息

Kawahara R, Hazama H, Kamase H, Takeshita H, Kunimoto N, Kayano M

出版信息

Folia Psychiatr Neurol Jpn. 1980;34(4):473-9. doi: 10.1111/j.1440-1819.1980.tb02453.x.

DOI:10.1111/j.1440-1819.1980.tb02453.x

PMID:7196368

Abstract

The diurnal rhythmicity of glutamic acid decarboxylase (GAD) activity in the nucleus level of the rat brain was examined by the radiochemical micromethod in a light-dark condition. GAD activity showed a biphasic variation in globus pallidus and substantia nigra (zona reticulata and compacta), but a monophasic variation, i.e. high in the dark, in colliculus superior (stratum griseum superficiale and stratum opticum). As for hypothalamus GAD activity of some nuclei (N. arcuatus, N. periventricularis, N. preopticus, etc.) it indicated a monophasic variation, while that of some nuclei (N. suprachiasmaticus, N. ventromedialis, A. lateralis, etc.) it showed no significant variations despite their proved functional activity with rhythmicity.

摘要

采用放射化学微量法，在明暗条件下检测大鼠脑内核水平谷氨酸脱羧酶（GAD）活性的昼夜节律性。苍白球和黑质（网状带和致密部）的GAD活性呈双相变化，而上丘（浅灰层和视层）的GAD活性呈单相变化，即黑暗中较高。至于下丘脑某些核团（弓状核、室周核、视前核等）的GAD活性呈单相变化，而某些核团（视交叉上核、腹内侧核、外侧核等）的GAD活性尽管已证实具有节律性功能活动，但未显示出明显变化。