Itani Z S, Ebert L, Greither A
Hautarzt. 1981 Jul;32(7):345-9.
A 28 year old African student had acquired a mycetoma of his left foot after an injury in 1975. As the surgical and antimycotic therapy had no effect, he was brought to Düsseldorf for the amputation of his foot. Madurella mycetomi was isolated from the skin, pus and bone. Before the amputation was made a last attempt to treat him with the antimycotic agent miconasol nitrate, administered intraarterially through the arteria tibialis posterior, which had been shown i arteriography to perfuse the whole foot. On the 23rd day of therapy pain and fever indicated bacterial infection. The fungus could still be isolated from the bone tissue. The therapy was terminated on the 30th day. The catheter was blocked and amputation of the food became inevitable. The patient received an artificial limb and is able to move freely. In similar cases of mycotic bone infection an attempt with intraarterial infusion of an antimycotic agent should be made immediately.
一名28岁的非洲学生在1975年脚部受伤后患上了足菌肿。由于手术和抗真菌治疗均无效，他被送往杜塞尔多夫进行截肢手术。从皮肤、脓液和骨头中分离出了马杜拉足分支菌。在进行截肢手术前，最后尝试通过胫后动脉动脉内注射抗真菌药物硝酸米康唑对他进行治疗，动脉造影显示该动脉灌注整个足部。治疗第23天，疼痛和发热表明发生了细菌感染。仍可从骨组织中分离出真菌。治疗在第30天终止。导管堵塞，截肢不可避免。患者安装了假肢，能够自由活动。在类似的真菌性骨感染病例中，应立即尝试动脉内输注抗真菌药物。
