Raju T N, Javed D I
J Natl Med Assoc. 1981 Aug;73(8):747-9.
A rare occurrence of severe, direct hyperbilirubinemia in an infant with BO incompatibility was noted at four hours of age. Severe fetal hemolysis and markedly elevated indirect bilirubin levels might have caused induction of conjugating enzymes during fetal life in this case. Intrahepatic cholestasis was responsible for persistent conjugated hyperbilirubinemia after birth. This responded favorably to cholestyramine therapy.
一名患有血型不合性溶血病的婴儿在出生后4小时出现了罕见的严重直接胆红素血症。严重的胎儿溶血和明显升高的间接胆红素水平可能在胎儿期诱导了结合酶的产生。出生后，肝内胆汁淤积导致了持续性结合胆红素血症。消胆胺治疗对此反应良好。
