Investigations of anthelminthic activity and synthesis of new derivatives of perhydroazepine, perhydro-1,4-diazepine, perhydro-1,4-oxazepine and perhydro-1,5-oxazocine.
作者信息
Glinka R, Grzywacz M, Kotełko B, Majchrzak M, Malinowski H, Mikołajewska H, Mikiciukolasik E, Szkukliński J
出版信息
Pol J Pharmacol Pharm. 1980 Sep-Oct;32(5):773-7.
PMID:7196575
Abstract
Anthelminthic activity of new esters of 3,4,5-trimethoxybenzoic acid containing rests of the title heterocyclic amines has been determined. 3-(Perhydroazepinyl)-propyl ester 6 acts on enchytraeids in vitro 56-fold stronger than piperazine adipate, 2-(perhydroazepinyl)-ethyl ester 5 is the most effective in a therapy of mice infested with nematodes.
摘要
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