Schröder M, König E, Niedner W, Grauel B M, Preibsch W
Zentralbl Gynakol. 1981;103(7):410-6.
Reported in this paper is experience obtained from antenatal RDS prophylaxis, using 4 mg of dexamethasone, on three consecutive days. Treatment was applied to 202 premature newborns, and these were compared with 252 untreated controls born on same term. Good success with statistical significance was recordable only from comparison between the two complete groups. - The mother's situations quite often were complicated by outbreak of infections in the wake of obstetric intervention for premature rupture of the amniotic sac. In view of the partial success of dexamethasone prophylaxis and with no alternative to glucocorticoid treatment so far available, continuation of RDS prophylaxis, using dexamethasone, is recommended, however, with strictest observance of contraindications and with higher doses.
本文报道了连续三天使用4毫克地塞米松进行产前预防呼吸窘迫综合征（RDS）的经验。对202例早产新生儿进行了治疗，并将其与252例同期出生的未治疗对照进行比较。只有在两组完整数据进行比较时才能记录到具有统计学意义的良好效果。——母亲的情况常常因胎膜早破的产科干预后感染爆发而变得复杂。鉴于地塞米松预防的部分成功，且目前尚无糖皮质激素治疗的替代方案，因此建议继续使用地塞米松进行RDS预防，但要严格遵守禁忌症并使用更高剂量。
