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暴露于电离辐射的小脑器官型培养物中浦肯野细胞轴突和突触前终末的形态学改变。

Morphological alterations of Purkinje cell axons and presynaptic terminals in organotypic cerebellar cultures exposed to ionizing irradiation.

作者信息

Baloyannis S J, Kim S U

出版信息

Acta Neuropathol. 1981;54(4):301-10. doi: 10.1007/BF00697004.

DOI:10.1007/BF00697004
PMID:7196672
Abstract

Ionizing irradiation induced marked morphological alterations in the Purkinje cell axons and axonic terminals in vitro. The myelinated segments demonstrated a very poor development of the myelin sheath. The axoplasm demonstrated various alterations of the mitochondria, and the smooth endoplasmic reticulum and the numerous elongated presynaptic terminals contained large aggregates of tubulovesicular structures and neurofilaments arranged in parallel and reticular array.

摘要

电离辐射在体外诱导浦肯野细胞轴突和轴突终末出现明显的形态学改变。有髓鞘节段的髓鞘发育非常差。轴浆中线粒体出现各种改变，滑面内质网以及众多细长的突触前终末含有大量呈平行和网状排列的微管泡结构和神经丝聚集体。

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An electron microscopic study of degenerative changes in the cat cerebellum after intrinsic and extrinsic lesions.
J Comp Neurol. 1966 Jan;126(1):15-36. doi: 10.1002/cne.901260102.
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Unusual neocortical presynaptic terminals in a patient with convulsions, mental retardation and cortical blindness: an electron microscopic study.一名患有惊厥、智力发育迟缓及皮质盲患者的异常新皮质突触前终末：一项电子显微镜研究
J Neuropathol Exp Neurol. 1965 Oct;24(4):539-62.
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Aggregates of irregular axoplasmic tubules in early Wallerian degeneration of guinea pig optic nerve.豚鼠视神经早期华勒氏变性中不规则轴浆小管的聚集体。
Brain Res. 1969 Aug;14(3):745-8. doi: 10.1016/0006-8993(69)90215-7.
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Electron microscopy of degeneration within the serotonin pathway of rat brain.大鼠脑内5-羟色胺通路退变的电子显微镜观察
Brain Res. 1969 Apr;13(2):266-73. doi: 10.1016/0006-8993(69)90286-8.
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Lab Invest. 1971 Dec;25(6):653-71.
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