Ogawa K, Wakamasu Y, Ito T, Suzuki T, Yamazaki N
Arzneimittelforschung. 1981;31(5):770-3.
Comparative coronary vasodilatory effects of nifedipine and niludipine were studied in normal anesthetized dogs. Nifedipine increased the coronary blood outflow by 142% at 2 min after administration of 10 micrograms/kg and the duration of the effect was over 30 min. On the other hand, niludipine increased the coronary blood outflow by 200% at 2 min after the injection of 25 micrograms/kg and the duration of the effect was over 60 min. Niludipine is a potent calcium antagonistic coronary vasodilator with less cardiodepressant effect than nifedipine. Both drugs are clinically useful as coronary vasodilators and hypotensive agents.
在正常麻醉犬中研究了硝苯地平和尼鲁地平的冠状动脉舒张作用比较。硝苯地平在给予10微克/千克后2分钟时使冠状动脉血流量增加了142%，且作用持续时间超过30分钟。另一方面，尼鲁地平在注射25微克/千克后2分钟时使冠状动脉血流量增加了200%，且作用持续时间超过60分钟。尼鲁地平是一种强效的钙拮抗型冠状动脉扩张剂，其对心脏的抑制作用比硝苯地平小。两种药物在临床上均可用作冠状动脉扩张剂和降压药。
