Zanolo G, Giachetti C, Mondino A, Silvestri S, Bianchi E, Segre G, Gomarasca P, De Marchi G
Arzneimittelforschung. 1981;31(7):1098-104.
Pharmacokinetic investigations were carried out on 2-phenyl-4-p-chlorophenyl-thiazol-5-ylacetic acid (fentiazac) in the rat and in the monkey. The drug, rapidly absorbed by the gastrointestinal system, shows a long maintenance in the body, with a long half-life in both animal species. The rate of biotransformation and the times of presence in the blood circulation of both unchanged drug and of its metabolites are indicated by the serum levels of cold fentiazac and labelled fentiazac. Urinary and fecal excretion attain levels amounting to 24 and 70%, respectively, of the dose administered.
对大鼠和猴子进行了2-苯基-4-对氯苯基噻唑-5-基乙酸（芬替扎ac）的药代动力学研究。该药物经胃肠道系统迅速吸收，在体内维持时间长，在两种动物物种中的半衰期都很长。冷芬替扎ac和标记芬替扎ac的血清水平表明了生物转化速率以及未变化药物及其代谢物在血液循环中的存在时间。尿液和粪便排泄量分别达到给药剂量的24%和70%。
