Phillips J I
Invest Urol. 1981 Sep;19(2):75-8.
An age related increased cellularity in the lamina propria of the mouse bladder is described. The identified cell types involved are plasma cells, lymphocytes, and eosinophilic leukocytes, and probably represent an inflammatory plasma cell infiltration. Two rare unidentified cell types were also seen. The cause of the inflammatory reaction is unknown, but the failure to detect a causative microorganism suggests that it might be an autoimmune response, possibly related to the clinical condition of interstitial cystitis. From foci of increased cellularity, located in the close proximity of blood vessels, lymphocytes migrate to the urothelium which otherwise shows no ultrastructural changes with age.
本文描述了小鼠膀胱固有层中与年龄相关的细胞增多现象。所鉴定出的相关细胞类型包括浆细胞、淋巴细胞和嗜酸性白细胞，这可能代表了一种炎性浆细胞浸润。还观察到两种罕见的未鉴定细胞类型。炎症反应的原因尚不清楚，但未能检测到致病微生物表明这可能是一种自身免疫反应，可能与间质性膀胱炎的临床状况有关。在靠近血管处的细胞增多灶中，淋巴细胞迁移至尿路上皮，而尿路上皮在其他方面未显示出随年龄增长的超微结构变化。
