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长骨中的细胞动力学与生长控制

Cell kinetics and the control of growth in long bones.

作者信息

Kember N F

出版信息

Cell Tissue Kinet. 1978 Sep;11(5):477-85. doi: 10.1111/j.1365-2184.1978.tb00820.x.

DOI:10.1111/j.1365-2184.1978.tb00820.x
PMID:719693
Abstract

The cell kinetics of the cartilage growth plate are outlined and discussed in terms of the probable levels of control on the system. Possible mechanisms of growth control at the cellular level are examined for (i) the rate of cell division in the proliferation zone, (ii) the command to differentiate that limits the size of the proliferation zone and (iii) the ageing process in the cartilage plate. The evidence of cell kinetics does not point unequivocally to any particular mechanism.

摘要

本文概述并讨论了软骨生长板的细胞动力学,涉及该系统可能的控制水平。从细胞水平研究了生长控制的可能机制,包括:(i)增殖区细胞分裂的速率;(ii)限制增殖区大小的分化指令;(iii)软骨板中的老化过程。细胞动力学的证据并未明确指向任何特定机制。

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