Adler S S, Trobaugh F E
Cell Tissue Kinet. 1978 Sep;11(5):555-66.
Peripheral blood values, femur cell counts, spleen weights, pluripotent (CFU-S) and granulocyte progenitor cell (CFU-C) concentrations and total content of spleens and femurs have been evaluated in intact (non-marrow-ablated) and 89Sr marrow-ablated S1/S1d and +/+ mice. 89Sr-irradiated mice were studied 6 and 11 days after the administration of 89Sr. In intact S1/S1d mice the femur CFU-S concentration, total femur CFU-S, femur CFU-C concentration and total femur CFU-C were 84, 54, 105 and 68% that of +/+ mice femurs respectively; the respective values for the spleens of S1/S1d mice were 40, 46, 61 and 69%. These are the first simultaneous determinations of CFU-S and CFU-C concentrations, and content of spleens and marrows, of S1/S1d and +/+ mice. In 98Sr marrow-ablated mice, 11 days after injection of the radionuclide: (a) the total content of marrow CFU-C and CFU-S was about 1% of that found in the marrows of intact mice for both +/+ and S1/S1d groups; (b) the spleens of +/+ mice increased in weight to 162% of the control, but the spleens of S1/S1d mice did not increase in weight; and (c) the spleens of +/+ mice had a total content of CFU-C and CFU-S of 800% and 260% of the control, respectively, whereas the respective values for the S1/S1d mice were 120% and 76% of the control. Thus the S1/S1d spleen fails to compensate for marrow ablation by housing additional CFU-S and has an impaired ability to compensate by housing additional CFU-C.
在完整（未进行骨髓消融）以及经89Sr进行骨髓消融的S1/S1d和+/+小鼠中，评估了外周血值、股骨细胞计数、脾脏重量、多能（CFU-S）和粒细胞祖细胞（CFU-C）浓度以及脾脏和股骨的总含量。对接受89Sr照射的小鼠在给予89Sr后第6天和第11天进行研究。在完整的S1/S1d小鼠中，股骨CFU-S浓度、股骨CFU-S总量、股骨CFU-C浓度和股骨CFU-C总量分别为+/+小鼠股骨的84%、54%、105%和68%；S1/S1d小鼠脾脏的相应值分别为40%、46%、61%和69%。这些是首次同时测定S1/S1d和+/+小鼠的CFU-S和CFU-C浓度以及脾脏和骨髓的含量。在经98Sr进行骨髓消融的小鼠中，在注射放射性核素11天后：（a）对于+/+和S1/S1d组，骨髓CFU-C和CFU-S的总含量约为完整小鼠骨髓中含量的1%；（b）+/+小鼠的脾脏重量增加至对照的162%，但S1/S1d小鼠的脾脏重量未增加；（c）+/+小鼠脾脏中CFU-C和CFU-S的总含量分别为对照的800%和260%，而S1/S1d小鼠的相应值分别为对照的120%和76%。因此，S1/S1d脾脏无法通过容纳额外的CFU-S来补偿骨髓消融，并且通过容纳额外的CFU-C进行补偿的能力受损。
