Colquhoun I, Bunday S
Med Hypotheses. 1981 May;7(5):673-9. doi: 10.1016/0306-9877(81)90014-1.
The Hyperactive Children's Support Group (HCSG) in an organisation with over 70 branches in Britain devoted to helping such children and their families. We have carried out a detailed survey of the characteristics of many of our children and their families and have studied the literature in detail. We have come to the conclusion that many of these children have a deficiency of essential fatty acids (EFAs) either because they cannot metabolise linoleic acid normally, or because they cannot absorb EFAs normally from the gut, or because their EFA requirements are higher than normal. The main pieces of evidence are: 1. Most of the food constituents which cause trouble in these children are weak inhibitors of the conversion of EFAs to prostaglandins (PGs). 2. Boys are much more commonly effected than girls and males are known to have much higher requirements for EFAs than females. 3. A high proportion of our children have abnormal thirst and thirst is one of the cardinal signs of EFA deficiency. 4. Many of our children have eczema, allergies and asthma which some reports suggest can be alleviated by EFAs. 5. Many of our children are deficient in zinc which is required for conversion of EFAs to PGs. 6. Some of of our children are badly affected by wheat and milk which are known to give rise to exorphins in the gut which can block conversion of EFAs to PGE1. A preliminary study of EFA supplementation in a number of our children has given promising results. We hope that others with better facilities will be encouraged to test out this hypothesis.
多动儿童支持小组(HCSG)是一个在英国拥有70多个分支机构的组织,致力于帮助这类儿童及其家庭。我们对许多儿童及其家庭的特征进行了详细调查,并对相关文献进行了深入研究。我们得出的结论是,这些儿童中有许多人缺乏必需脂肪酸(EFA),原因要么是他们不能正常代谢亚油酸,要么是他们不能从肠道正常吸收必需脂肪酸,要么是他们对必需脂肪酸的需求量高于正常水平。主要证据如下:1. 这些儿童中引发问题的大多数食物成分都是必需脂肪酸向前列腺素(PG)转化的弱抑制剂。2. 男孩比女孩受影响的情况更为普遍,而且已知男性对必需脂肪酸的需求量比女性高得多。3. 我们的儿童中有很大一部分有异常口渴的情况,而口渴是必需脂肪酸缺乏的主要症状之一。4. 我们的许多儿童患有湿疹、过敏和哮喘,一些报告表明必需脂肪酸可以缓解这些症状。5. 我们的许多儿童缺锌,而锌是必需脂肪酸转化为前列腺素所必需的。6. 我们的一些儿童受到小麦和牛奶的严重影响,已知它们会在肠道中产生外啡肽,从而阻碍必需脂肪酸转化为前列腺素E1。对我们一些儿童补充必需脂肪酸的初步研究取得了令人鼓舞的结果。我们希望其他条件更好的人会受到鼓励来验证这一假设。